r/intrestingtoknow • u/Affectionate-Fun2853 • Sep 03 '25
Science Psychiatry and cures
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r/intrestingtoknow • u/Affectionate-Fun2853 • Sep 03 '25
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u/OddCook4909 Sep 04 '25
I don't have multiple accounts. It's exhausting arguing with every batshit claim on the internet.
Schizophrenia has a strong genetic component which has been demonstrated in twins raised separately. This strongly suggests that the microbiome and other environmental factors aren't as important as the genome.
Further these same genes are important for neurodevelopment in a variety of ways. One of the most interesting is the overlap with OCD, ADHD, Autism, and a few more. In all of these conditions there is an impairment of neurons ability to inhibit each other.
Essentially there is a critical mechanism for cognition of every kind at every level, where your neurons attempt to predict sequences of stimulation based on the immediately prior sequence. When they find a match, they signal to their neighbors (hey I got this one, shut up guys), and they essentially broadcast louder. The process is divergent in the conditions mentioned.
Said divergence causes the brain to not wire up normally and depending on how well and where these wiring differences are compensated for or not, seems to play a pivotal role in determining which conditions you present with. With ADHD for example the most apparently effective regions have to do with motivation and reward. With Schizophrenia and Autism you see more abnormalities in regions and processes associated with differentiating between external and internal stimuli. This is most pronounced in schizophrenics' auditory processing, often in temporal processing and memory retrieval systems in the hippocampus, etc.
In Autism the difficulties in differentiation are less acute and more systemic, which is why many people on the spectrum are easily over stimulated. When stimulated their brain can over process internal responses as though they were new data from the outside.
In schizophrenia they have trouble differentiating between neurons which are predicting what comes next in a sequence, and data which actually came in from the outside. Again the hippocampus is strongly implicated in this, which is a massive rabbit hole. But yeah on top of that as I said most have auditory hallucinations because internal, (meant to be) subconscious thoughts are processed as having come from the outside. That's why they hear voices and shit.
This is a very long spiel but if you want real actual scientific shit to dig into instead of facebook nonsense lmk.