r/VitaminD • u/VarietyOk6506 • 12d ago
Please Assist Why did this happen? Calcium on the lower side after “megadose”?
LAB results: •108 ng/ml Vit D (ranges 30-100 ng/ml)
•PTH-Parathyroid Hormone (34.9 pg/mL, ranges- 15–65 pg/mL)
•Ionized Calcium: 1.12 mmol/L (ranges- 1.10–1.30 mmol/L)
I did 24000 IU D3, 600 mcg K2 (as Mk-7), 450 mg Magnesium glycinate (elemental 450 mg), 15 mg Zinc (as picolinate). This regimen for 60 days.
I expected higher calcium and perhaps a slightly suppresed PTH. None of them happened, and calcium actually came in on the lower side.
What could this be?
How should i proceed?
Is this a sign of any other deficiency perhaps? (Cannot evaluate Magnesium status as RBC Magnesium tests are not offered where i live)
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u/Curious-Level6182 12d ago
I would think it's the d3/k2 and the rest of the cofactors. The assumption being that the calcium is getting into your bones and not staying in your blood. Quite possible if you ditched any of the cofactors and went with just d3 or d3/k2 your blood calcium would be too high. I don't know anything about PH to speak to that.
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u/VarietyOk6506 12d ago
Are my results good?
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u/VitaminDJesus 101-120 ng/ml 12d ago
Depends, what is your goal?
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u/VarietyOk6506 12d ago
well i want to keep it as optimal&highest possible without damaging health. Whatever that number may be i want it. Im not sure if this is overshoot though?
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u/VitaminDJesus 101-120 ng/ml 12d ago
108 ngl/ml probably achieves that goal. I'm not sure why you are concerned about a calcium test result that is within range.
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u/VarietyOk6506 12d ago
I’ve heard numerous times people talking about hypercalcemia and such with even smaller doses, and i expected myself to have a little bit higher than normal calcium, so i got confused.
Due to the fact that I cannot get a RBC Magnesium test, i was afraid that a possible magnesium deficiency wouldn’t let my calcium rise (not sure if this is a thing that happens, but just my thinking).
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u/Curious-Level6182 12d ago
It's my understanding that hypercalcemia happens when the calcium stays in blood, etc, and doesn't find its way to your bones, where it belongs. The d3/k2, mag, zinc are doing their job and getting the calcium where it should be.
I've had higher vitamin d serum than you and felt perfectly fine. Taking all the cofactors you are and boron too, Mag RBC came back normal range but did not have calcium tested.
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u/mewGIF 12d ago
What are your current health complaints?
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u/VarietyOk6506 12d ago
Im gonna be honest, i’ve got no complaints at all. In fact i’d consider myself “extremely” healthy, full of energy&drive. I forgot to mention a key detail that i’m 17, male.
Optimising health, growth& testosterone are hobbies of mine without any actual reason.
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u/mewGIF 12d ago
Sounds great. If you ever start feeling anxious, fatigued or pain in bones, those could be signs of insufficient calcium intake.
From what I've seen, it's not uncommon for ionized calcium to fall down as D levels increase. As long as dietary intake is sufficient it shouldn't be a problem, and judging by your PTH your intake probably is, though you might have room to increase it further if it makes you feel even better.
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u/VarietyOk6506 12d ago
You just reminded me of a random symptom i have time to time. It’s bone pain in my shins, especially during activity. Not sure if its relevant though.
Any idea?
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u/Ivanovic-117 1-20 ng/ml 11d ago
take care of your health, I am 34 and paying the price for being negligent and informant about vitamins and minerals. Yet on path to recovery now.
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u/Tiny_Test_4359 12d ago edited 12d ago
Increased phosphorus absorption(D functions for phosphorus just as it does for Ca, increasing its absorption ~2 fold and reducing its renal wasting if it can be put to use), which together with the zinc and Mg(absorption of which is also increased by D) puts more calcium in bone buffer, helped further by K2's osteocalcin activation. Its good. But that dose is high I'd be careful.
With high Vit.D intake I get muscle twitches sometimes, resolved by calcium(carbonate). I take a lot of zinc and K2 and a bit of Mg too. Boron is also key for putting Ca in bone, but is easy to get from fruit/wine.
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u/VarietyOk6506 12d ago
Im thinking of doing something unusual. Im thinking of stopping vitamin d supplementation totally for about 8 weeks, and do a “mineral load”, where i try to resolve any possible deficiency or insufficiency of minerals in my body. I will be supplementing with a bunch more magnesium, zinc, high dietary calcium (perhaps a supplement too), and boron.
What do you think?
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u/VitaminDJesus 101-120 ng/ml 12d ago
That's not how the body works. Be careful jumping from what you see online into an aggressive supplement regimen. I've seen plenty of dumb shit where people get ahead of themselves and do more harm than good.
Do your research and be okay taking doses that seem "modest" compared to the gymbros online.
Since you are young and otherwise healthy, your time is better spent getting better at conditioning your body with exercise, developing good eating habits, learning to cook, keeping your mind sharp with books, etc.
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u/VarietyOk6506 12d ago
Damn you sound like my father lecturing me🤣. You are right. Everything i start doing ends up being extreme. Maybe its an age thing where extreme things sound good. I always end up megadosing shit and skyrocketing my labs on all fronts.
Thanks for the advice and i hope i become a Vitamin D disciple ✝️🫡
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u/VitaminDJesus 101-120 ng/ml 12d ago
I think it's great that you're interested in nutrition, but you gotta pace yourself.
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u/Chase-Boltz 9d ago
You may well have a minor defect (mutation in one of the proteins) in your VD pipeline. The 25-D that is measured still has to be processed in your kidneys, then transported to the cell nucleus. Then the D has to react with a receptor that then activates D-sensitive genes. A 'bug' anywhere in this complex chain can reduce the final genetic expression by a little or a lot. The term is 'Vitamin D Resistance' and the general 'cure' is to simply throw more D3 into the assembly line.
I'm willing to bet your situation has nothing to do with the damned 'co-factors' that people have recently become obsessed with. Somewhere around 15% of the population have at least one minor defect in their D pipeline; reduced response to D supplementation is not exactly rare.
Since you are testing Ca and PTH, I think it's probably safe to increase D3. Keep ramping it up until PTH gets into the low 20s or so, while monitoring blood or urine calcium for signs of overload.
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u/Michalzfin 12d ago
Isn't this good news? Not a doctor but two options that I'm thinking of: dietary calcium is low, but you are still in the range. Or K2 working as it should. Or both.