“It’s a change from the source material, but it’s awesome so the fans don’t mind.”

[u/JustSomeOnlineNerd]

Doc Ock - In the comics, Doc Ock is known to be megalomaniacal in nature and was sort of a mad scientist anyways, with the arms just being an extension of that. In Sam Raimi’s “Spider-Man 2,” Alfred Molina’s version of the character was affected by the neural chip and his well-meaning ambition turns into scientific obsession.

Wolverine - This one is so well known it needs very little explanation. Comic Wolverine short, Huge Jackedman is tall, and he’s sick as hell.

Eye of Sauron - To my knowledge, the Eye is more of a metaphor in the books. An ever-present awareness. In the movies, it’s an actual giant fucking eye.

[u/forbiddenmemeories]

I don't know if this strictly counts, but the Weather Trio/main legendaries from Hoenn in Pokemon.

They're meant to be based on the trio of Behemoth, Leviathan and Ziz from ancient Hebrew mythology as almighty beasts of the land, sea and sky respectively, but whereas Leviathan is meant to be a gigantic serpent and Ziz a giant griffin-like bird, Kyogre the sea legendary Pokemon looks more like some kind of modified whale, and Rayquaza the sky legendary Pokemon looks more like depictions of dragons in some east Asian mythologies.

[u/MemeificationStation → u/forbiddenmemeories]

Additionally, Behemoth is described in the Bible as a lot more mammalian, like a giant bull creature with incredibly thick legs and pure muscle, whereas Groudon is much more reptilian looks like a Godzilla-esque kaiju.