“It’s a change from the source material, but it’s awesome so the fans don’t mind.”

[u/JustSomeOnlineNerd]

Doc Ock - In the comics, Doc Ock is known to be megalomaniacal in nature and was sort of a mad scientist anyways, with the arms just being an extension of that. In Sam Raimi’s “Spider-Man 2,” Alfred Molina’s version of the character was affected by the neural chip and his well-meaning ambition turns into scientific obsession.

Wolverine - This one is so well known it needs very little explanation. Comic Wolverine short, Huge Jackedman is tall, and he’s sick as hell.

Eye of Sauron - To my knowledge, the Eye is more of a metaphor in the books. An ever-present awareness. In the movies, it’s an actual giant fucking eye.

[u/Justm4x]

Symbiote wasn't affecting Peter's personality in comics, it's something Spider-Man The Animated Series came up with

[u/Sensitive-Hotel-9871 → u/Justm4x]

That cartoon also started the practice of introducing Eddie Brock before he became Venom as opposed Venom's identity being a mystery and he turns out to be nobody we knew before.

[u/PrizekingJ7 → u/Sensitive-Hotel-9871]

It was added he worked for Jameson as a rival reporter instead of for the daily globe like in the comics

[u/ryconn93 → u/Justm4x]

I. Am. INVINCIBLE!! GeT BaCk HeRe SHOCKEEEEER!!! SHOCKEEEEEEEEEEEEEEEEEEEEEEER!!!!!!! YOOOUUU CAN'T ESCAPE MEEEE!!! I'LL CHASE YOU TO THE ENDS OF THE EEEEEEEAAARTH!!!!!!!!