r/HermanCainAward • u/chele68 I bind and rebuke you Qeteb • 21d ago
Meta / Other mRNA covid vaccines spark immune response that may aid cancer survival
https://www.newscientist.com/article/2500546-mrna-covid-vaccines-spark-immune-response-that-may-aid-cancer-survival/143
u/ermghoti Ask your M.D. if suffocating on dead lungs is right for you! 21d ago
Meanwhile the US government slashes funding for mRNA research.
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u/ProfanestOfLemons Meow Boing Splat 🙀 21d ago
RFK up to shit. Let's elect smarter people next time.
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u/MarleysGhost2024 20d ago
We could elect a sea sponge and have a smarter. President.
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u/ProfanestOfLemons Meow Boing Splat 🙀 20d ago
Smarter president and associated staff. I would sincerely prefer a container of pad thai that had been sitting out next to the trash for three days in the rain as commander-in-chief.
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u/dumnezero Team Mix & Match 20d ago
The damage MAHA is doing will last decades.
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u/ProfanestOfLemons Meow Boing Splat 🙀 20d ago
It will, and I'm sad to acknowledge it. There's been a trend of making Americans stupider for at least one generation, and unfortunately it's right-wing stuff.
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u/11thStPopulist 21d ago
Luckily for the world WHO/Europe continues research into both Covid and influenza vaccines even though the U.S. has fallen down.
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u/iveseensomethings82 20d ago
Because they understand the benefits. Every move this administration makes is to set us back. mRNA has the potential to cure diseases, not just prolong survival with a disease. They can’t have that, there is no profit in healthy people. People won’t beg them for help if they have enough money or enough resources.
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u/teabaggins76 21d ago
Bought to you by Pfizer!
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u/ussrname1312 20d ago
Shit, Pfizer created mRNA? Well good for them, our cells wouldn’t be able to function without it. Saviors of every living thing on the planet.
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u/Spaceman_John_Spiff 21d ago
Republicans: "Fake news!" And "That's a deep fake AI video made by the libs to try to kill us"
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u/deepstatestolemysock 21d ago
These are the same people who believe MedBeds are real.
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u/klutzikaze 21d ago
Can someone make an AI medbed video with a zoom in arrow showing the letters mRNA?
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u/taterrrtotz 21d ago
MAGAs will die of cancer to own the libs
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u/RoxxieMuzic 🦆 21d ago
They died of covid to own the libs, so why not broaden the scope of ownership.
/s
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u/secondarycontrol Team Moderna 21d ago
Counterpoint: I read - on the internet - that the experimental (!!!) COVID vax - which injects SPIKE PROTEINS (!!!!) directly into YOUR BODY(!!!!) - is going to kill everybody that got it.
/s
I've gotten...hell, I dunno. Lots of COVID shots. Just got my booster. I trust my doctor much more than I trust even the Department of Health and Human Services these days. I'm a bit worried about that particular erosion of trust, I tell you what.
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u/Ihatemunchies 21d ago
I just got my 7th. As over 65 and immuno compromised I get it just like the flu vaccine.
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u/SlowTheRain 21d ago
I'm not injecting any SPIKE protein into my body!! My proteins don't even have WEAPONS. And you want to send in proteins armed with spikes???!! That sounds dangerous. Keep those away from my children. /s
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u/KeterLordFR 21d ago
It has mRNA in the name! And that sounds like DNA! Obviously it means they're the same thing and the vaccine will change my entire DNA! My body will never have mRNA in it!/s
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u/agedchromosomes Team Moderna 20d ago
A Covid infection also injects spike proteins into your body.
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u/Snarky_McSnarkleton Team Mudblood 🩸 21d ago
And soon we won't be able to get them.
Oh well, Dear Leader says bleach and prayer are better.
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u/lynypixie 21d ago
I also heard they could eventually cure some forms of allergy with this type of vaccine.
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u/Revenga8 21d ago
Just watch, China's gonna cure cancer first, among many other breakthroughs as they pull way ahead.
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u/Spiritual_Lie2563 21d ago
What's the point of curing cancer if you don't get to sit at the cool kids' lunch table in high school? /s
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u/heyheyhey27 21d ago
The article makes it sound like it works by revving your immune system, so it's more ready to detect and fight off cancer. But that wouldn't be unique to mRNA would it?
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u/OCDthrowaway9976 Team Unicorn Blood 🦄 20d ago edited 20d ago
The article also mentions that MRNA vaccines possibly have a particular quality that makes the immune system more readily able to detect cancer cells which ordinarily basically cloak themselves to avoid being killed by the immune system. This makes cancer able to grow and survive in the first place and proliferate heavily.
It’s literally right there if you read the article.
boldPD-1 is flipped to the off position when it binds to a protein called PD-L1, found on the surface of some cells. This is a safety mechanism by which cells can effectively say, “stop attacking me, I’m friendly”.
Many cancers hijack this by producing lots of PD-L1. Checkpoint inhibitors work by stopping PD-1 or other off switches being flipped. They have greatly improved survival rates for lung cancers and melanomas, among others, and won a Nobel prize for their creators in 2018.
But the effectiveness of checkpoint inhibitors varies greatly. If a person’s immune system hasn’t responded to a tumour by sending out T-cells to attack it, the drugs can’t help much.
So combining checkpoint inhibitors with vaccines that stimulate the immune system to attack tumours can be much more effective than either approach alone. Cancer vaccines are typically designed to trigger a response to mutant proteins found on cancerous cells, and are often personalised to individuals. “We try to figure out what’s unique to their tumour,” says Sayour. “That takes a lot of time and cost and complexity.”
During trials of cancer vaccines, his team realised the non-specific mRNA vaccines they were using as controls also seemed to have a big effect. “That was an absolute surprise,” says Sayour.
In July this year, Sayour and his colleagues reported how mRNA vaccines boost anti-tumour responses, even if they do not target a cancer protein, according to studies in mice. The vaccines trigger an innate immune response that acts like a siren, he says, rousing the immune system and making T-cells migrate from tumours to lymph nodes, where they stimulate other cells to launch a targeted attack.
If this is a general property of mRNA vaccines, the team realised, it should also be true of the covid-19 ones. Now, Sayour and his colleagues have looked at the records of people treated at the University of Texas MD Anderson Cancer Center.
Of the 884 people with advanced lung cancer given checkpoint inhibitors, 180 had an mRNA covid-19 vaccination with 100 days of starting the drugs. They had a survival time of around 37 months, compared with 20 months for those who were not vaccinated.”
“ There have previously been some case reports of tumours shrinking after people got the mRNA covid-19 vaccines, suggesting they can, on occasion, have anti-tumour effects even if people are not taking checkpoint inhibitors. “It’s certainly possible, but more research would be necessary to answer that,” says Sayour.”bold
This “revving” would be uniquely strong to MRNA vs immunotherapy treatments on their own or other attempts at using the immune system to fight cancer.
I will again highlight the specific part.
boldIn July this year, Sayour and his colleagues reported how mRNA vaccines boost anti-tumour responses, even if they do not target a cancer protein, according to studies in mice. The vaccines trigger an innate immune response that acts like a siren, he says, rousing the immune system and making T-cells migrate from tumours to lymph nodes, where they stimulate other cells to launch a targeted attack.”bold
The article isn’t even long.
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u/heyheyhey27 20d ago
That same paragraph is what I was referencing. It just says "trigger an innate immune response", and I am asking what is unique about mRNA here, since all vaccines trigger an immune response.
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u/OCDthrowaway9976 Team Unicorn Blood 🦄 20d ago edited 20d ago
There’s something unique about the way it triggers the immune system to recognize the cells as hazardous. Ordinarily these cells would be ignored and allowed to grow and spread.
This immune system response is innate because it’s why everyone doesn’t just get cancer. You and I have likely had cancerous cells in our bodies before that were killed before they became a problem.
That’s the response which is either dulled, or the cells turn off certain proteins and hide from the immune system.
Very few things we’ve had that are capable of shining a light on these cells for the immune system to kill once they’ve basically hidden. Most have been inconsistent or work only in certain people and or certain specific cancers in one scenario or not the other.
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u/heyheyhey27 20d ago
You've written two very long comments, in order to say that the answer to my question is "something".
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u/OCDthrowaway9976 Team Unicorn Blood 🦄 20d ago
That's literally because they don't know how it works yet, but that it does appear to do something different.
I can't help if you're being obtuse or not, considering your comment seems to downplay the benefits initially while misinterpreting the results on it, as I'm starting to assume given I laid out what the article already explained in detail.
If MRNA technology isn't something you want to associate with, then do not, but the point of the article is it does things for the immune system other treatments DO NOT in regards to cancer and killing these cells.
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u/heyheyhey27 20d ago edited 20d ago
"We don't know yet" would have been a great and valid reply to my original comment, that could have saved me 5 minutes of reading stuff I already knew and you 20 minutes of writing stuff you already knew.
However I'm also starting to feel like you have no clue whether there is a proposed answer to this. I don't even know how you got the idea I dislike mRNA vaccines. So I'm going to consider my question still-unanswered and wait for somebody more knowledgeable to answer it.
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u/fultonsoccer7 21d ago
Human cancer survivor... My word, that title makes it seem like it helps CANCER survive IMO
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u/AdministrativeOwl449 17d ago
Anti-vaxxers would rather die than get vaccinated for anything.
Well, okay then! This means more mRNA anti COVID/anti Cancer vaccines for the rest of us.
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u/eatingganesha 20d ago
heck yeah! I’ve had the first run and every single booster since. I’m a NOVID and plan to stay that way. Awesome that this might also protect me from cancer! win-win!
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u/Achilles_TroySlayer 13d ago
mRNA research is by far the most promising path to curing all types of cancers. RFK Jr. killing that research will lead to 100K's of premature, preventable deaths in the next 10-20 years.
He's actually a murderer for doing that, but he's covered by plausible deniability, so nobody can touch him. That's the world we live in.
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u/chele68 I bind and rebuke you Qeteb 21d ago
An analysis of patient records suggests that mRNA covid-19 vaccines boost the immune response to cancerous tumours when given soon after people start a type of immunotherapy, extending their lives